Targets / Kinase / CDK8

cyclin-dependent kinase 8 (CDK8)

Target Class
Kinase
Family
CMGC
Official Symbol
CDK8
Entrez Gene ID
1024
Species
Human
Accession Number
NP_001251.1
Alias Names
CDK8 protein kinase; K35; cell division protein kinase 8; cyclin-dependent kinase 8; mediator complex subunit CDK8; mediator of RNA polymerase II transcription subunit CDK8; protein kinase K35
Background
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery. [provided by RefSeq, Jul 2008]
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Related Group Members: CMGC
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