Targets / Kinase / CHEK1

checkpoint kinase 1 (CHEK1)

Target Class
Kinase
Family
CAMK
Official Symbol
CHEK1
Entrez Gene ID
1111
Species
Human
Accession Number
NP_001265.2
Alias Names
CHK1; CHK1 (checkpoint, S.pombe) homolog; CHK1 checkpoint homolog; CHK1 checkpoint homolog (S. pombe); Checkpoint, S. pombe, homolog of, 1; Chk1-S; cell cycle checkpoint kinase; checkpoint kinase 1; checkpoint kinase-1; serine/threonine-protein kinase Chk1
Background
The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]
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Related Group Members: CAMK
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