Targets / Kinase / CLK4

CDC-like kinase 4 (CLK4)

Target Class
Kinase
Family
CMGC
Official Symbol
CLK4
Entrez Gene ID
57396
Species
Human
Accession Number
NP_065717.1
Alias Names
CDC-like kinase 4; dual specificity protein kinase CLK4; protein serine threonine kinase Clk4
Background
The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined. [provided by RefSeq, Jul 2008]
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Related Group Members: CMGC
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