Targets / Kinase / DLK

mitogen-activated protein kinase kinase kinase 12 (DLK)

Target Class
Kinase
Family
TKL
Official Symbol
MAP3K12
Entrez Gene ID
7786
Species
Human
Accession Number
NP_006292.2
Alias Names
DLK; MAPK-upstream kinase; MEKK12; MUK; ZPK; ZPKP1; dual leucine zipper bearing kinase; dual leucine zipper kinase DLK; leucine zipper protein kinase; mitogen-activated protein kinase kinase kinase 12; mixed lineage kinase; protein kinase MUK
Background
This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010]
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