Targets / Kinase / GHR-JAK2
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Growth hormone receptor (GHR-JAK2)

Target Class
Kinase
Family
Cytosolic Tyrosine Kinase
Official Symbol
GHR-JAK2
Species
Human
Accession Number
NM_000163
Alias Names
GH receptor; GHBP; growth hormone binding protein; growth hormone receptor; serum binding protein; somatotropin receptor
Background
This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]
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Solution Portfolio

Related Group Members: Cytosolic Tyrosine Kinase
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Cell Lines
Assay Measures Background Species Cell Line
Receptor Phosphorylation U2OS Human 93-0829C3
Ready to Use eXpress Kits
Assay Measures Background Species Assay Kit
Receptor Phosphorylation U2OS Human 93-0829E3CP14M
Receptor Phosphorylation U2OS Human 93-0829E3CP14L
LeadHunter Screening & Profiling Services
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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