Targets / Kinase / HASPIN

germ cell associated 2 (haspin) (HASPIN)

Target Class
Kinase
Family
Other
Official Symbol
GSG2
Entrez Gene ID
83903
Species
Human
Accession Number
NP_114171.2
Alias Names
H-haspin; HASPIN; germ cell associated 2 (haspin); germ cell-specific gene 2 protein; haploid germ cell-specific nuclear protein kinase; serine/threonine-protein kinase haspin
Background
Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.
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