Targets / Kinase / JAK3(JH1domain-catalytic)

Janus kinase 3 (JAK3(JH1domain-catalytic))

Target Class
Kinase
Family
TK
Official Symbol
JAK3
Entrez Gene ID
3718
Species
Human
Accession Number
NP_000206.2
Alias Names
JAK-3; JAK3_HUMAN; JAKL; Janus kinase 3; Janus kinase 3 (a protein tyrosine kinase, leukocyte); L-JAK; LJAK; leukocyte Janus kinase; tyrosine-protein kinase JAK3
Background
The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq, Jul 2008]
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Related Group Members: TK
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