Targets / Kinase / LATS2

large tumor suppressor kinase 2 (LATS2)

Target Class
Kinase
Family
AGC
Official Symbol
LATS2
Entrez Gene ID
26524
Species
Human
Accession Number
NP_055387.1
Alias Names
KPM; LATS (large tumor suppressor, Drosophila) homolog 2; LATS, large tumor suppressor, homolog 2 (Drosophila); kinase phosphorylated during mitosis protein; large tumor suppressor homolog 2; serine/threonine kinase KPM; serine/threonine-protein kinase LATS2; serine/threonine-protein kinase kpm; warts-like kinase
Background
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]
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Related Group Members: AGC
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