Find a Product

serine/threonine kinase 10 (LOK)

Target Class
Kinase
Family
STE
Official Symbol
STK10
Entrez Gene ID
6793
Species
Human
Accession Number
NP_005981.3
Alias Names
LOK; PRO2729; lymphocyte-oriented kinase; serine/threonine kinase 10; serine/threonine-protein kinase 10
Background
This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008]
+ Show More


Solution Portfolio

Related Group Members: STE
?

DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
Available