Targets / Kinase / LOK

serine/threonine kinase 10 (LOK)

Target Class
Kinase
Family
STE
Official Symbol
STK10
Entrez Gene ID
6793
Species
Human
Accession Number
NP_005981.3
Alias Names
LOK; PRO2729; lymphocyte-oriented kinase; serine/threonine kinase 10; serine/threonine-protein kinase 10
Background
This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008]
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Related Group Members: STE
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