Biological Information | |
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Background Information: | The Lyn protein is a member of the Src family of non-receptor-associated protein-tyrosine kinases. LYN A differs from LYN B in having an additional 21 amino acids at the amino terminus. Lyn undergoes a concentration-dependent autophosphorylation, thus activating the catalytic site and decreasing the accessibility of the SH2 domain. Lyn phosphorylates and activates Tec, non-receptor tyrosine kinase that is coexpressed with Lyn and acts downstream of Lyn in intracellular signaling pathways. Lyn tyrosine kinase has been shown to be necessary for IgE-receptor (FceRI)-mediated mast-cell activation.
EMBL M16038 |
Target Class: | Kinase |
Accession Number: | NM_002350.1 |
Target Name: | Lyn |
Target Aliases: | LYN, JTK8, FLJ26625 |
Target Species: | Human |
Usage | |
Product Type: | Enzymes |
Application: | Drug Discovery & Development |
Storage Conditions: | 6 months at -70°C |
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14-510x Datasheet
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