Targets / Kinase / MAP4K3

mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3)

Target Class
Kinase
Family
STE
Official Symbol
MAP4K3
Entrez Gene ID
8491
Species
Human
Accession Number
NP_003609.2
Alias Names
GLK; MAPK/ERK kinase kinase kinase 3; MAPKKKK3; MEK kinase kinase 3; MEKKK 3; RAB8IPL1; germinal center kinase-like kinase; germinal center kinase-related protein kinase; mitogen-activated protein kinase kinase kinase kinase 3
Background
This gene encodes a member of the Ste20 family of serine/threonine protein kinases. The protein belongs to the subfamily that consists of members, such as germinal center kinase (GCK), that are characterized by an N-terminal catalytic domain and C-terminal regulatory domain. The kinase activity of the encoded protein can be stimulated by UV radiation and tumor necrosis factor-alpha. The protein specifically activates the c-Jun N-terminal kinase (JNK) signaling pathway. Evidence suggests that it functions upstream of mitogen-activated protein kinase kinase kinase 1 (MEKK1). This gene previously was referred to as RAB8-interacting protein-like 1 (RAB8IPL1), but it has been renamed mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3). [provided by RefSeq, Jul 2008]
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