Targets / Kinase / MAP4K4

mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4)

Target Class
Kinase
Family
STE
Official Symbol
MAP4K4
Entrez Gene ID
9448
Species
Human
Accession Number
NP_663719.1
Alias Names
FLH21957; HGK; HPK/GCK-like kinase HGK; MAPK/ERK kinase kinase kinase 4; MEK kinase kinase 4; MEKKK4; NIK; Ste20 group protein kinase HGK; hepatocyte progenitor kinase-like/germinal center kinase-like kinase; mitogen-activated protein kinase kinase kinase kinase 4; nck-interacting kinase
Background
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
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