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mitogen-activated protein kinase kinase kinase kinase 5 (MAP4K5)

Target Class
Kinase
Family
STE
Official Symbol
MAP4K5
Entrez Gene ID
11183
Species
Human
Accession Number
NP_006566.2
Alias Names
GCKR; KHS; KHS1; MAPK/ERK kinase kinase kinase 5; MAPKKKK5; MEK kinase kinase 5; MEKKK 5; germinal center kinase-related; kinase homologous to SPS1/STE20; mitogen-activated protein kinase kinase kinase kinase 5
Background
This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
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Related Group Members: STE
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KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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