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mitogen-activated protein kinase kinase 6 (MEK6)

Target Class
Kinase
Family
STE
Official Symbol
MAP2K6
Entrez Gene ID
5608
Species
Human
Accession Number
NP_002749.2
Alias Names
MAPK/ERK kinase 6; MAPKK 6; MAPKK6; MEK 6; MEK6; MKK6; PRKMK6; SAPK kinase 3; SAPKK-3; SAPKK3; dual specificity mitogen-activated protein kinase kinase 6; mitogen-activated protein kinase kinase 6; protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6); stress-activated protein kinase kinase 3
Background
This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008]
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