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met proto-oncogene (hepatocyte growth factor receptor) (MET(M1250T))

Target Class
Kinase
Family
TK
Official Symbol
MET
Entrez Gene ID
4233
Species
Human
Accession Number
NP_000236.2
Alias Names
AUTS9; HGF receptor; HGF/SF receptor; HGFR; RCCP2; SF receptor; c-Met; hepatocyte growth factor receptor; met proto-oncogene (hepatocyte growth factor receptor); met proto-oncogene tyrosine kinase; oncogene MET; proto-oncogene c-Met; scatter factor receptor; tyrosine-protein kinase Met
Background
The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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Related Group Members: TK
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KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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