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misshapen like kinase 1 (MINK)

Target Class
Kinase
Family
STE
Official Symbol
MINK1
Entrez Gene ID
50488
Species
Human
Accession Number
NP_001020108.1
Alias Names
B55; GCK family kinase MINK; MAP4K6; MAPK/ERK kinase kinase kinase 6; MEK kinase kinase 6; MEKKK 6; MINK; YSK2; ZC3; hMINK; hMINKbeta; misshapen-like kinase 1; misshapen-like kinase 1 (zebrafish); misshapen/NIK-related kinase; mitogen-activated protein kinase kinase kinase kinase 6; serine/threonine protein kinase
Background
This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
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Related Group Members: STE
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