Targets / Kinase / MLK2

mitogen-activated protein kinase kinase kinase 10 (MLK2)

Target Class
Kinase
Family
TKL
Official Symbol
MAP3K10
Entrez Gene ID
4294
Species
Human
Accession Number
NP_002437.2
Alias Names
MEKK10; MKN28 derived nonreceptor_type serine/threonine kinase; MKN28 kinase; MLK2; MST; mitogen-activated protein kinase kinase kinase 10; mixed lineage kinase 2; protein kinase MST
Background
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008]
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Related Group Members: TKL
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