Targets / Kinase / MST1

serine/threonine kinase 4 (MST1)

Target Class
Kinase
Family
STE
Official Symbol
STK4
Entrez Gene ID
6789
Species
Human
Accession Number
NP_006273.1
Alias Names
KRS2; MST-1; MST1; STE20-like kinase MST1; YSK3; dJ211D12.2 (serine/threonine kinase 4 (MST1, KRS2)); kinase responsive to stress 2; mammalian STE20-like protein kinase 1; mammalian sterile 20-like 1; serine/threonine kinase 4; serine/threonine-protein kinase 4; serine/threonine-protein kinase Krs-2
Background
The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]
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