Targets / Kinase / MST4

serine/threonine protein kinase MST4 (MST4)

Target Class
Kinase
Family
STE
Official Symbol
MST4
Entrez Gene ID
51765
Species
Human
Accession Number
NP_057626.2
Alias Names
MASK; Mst3 and SOK1-related kinase; STE20-like kinase MST4; mammalian Ste20-like protein kinase 4; mammalian sterile 20-like 4; serine/threonine protein kinase MST4; serine/threonine-protein kinase MASK; serine/threonine-protein kinase MST4
Background
The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
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Related Group Members: STE
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