Targets / Kinase / MYO3A

myosin IIIA (MYO3A)

Target Class
Kinase
Family
STE
Official Symbol
MYO3A
Entrez Gene ID
53904
Species
Human
Accession Number
NP_059129.3
Alias Names
DFNB30; deafness, autosomal recessive 30; myosin IIIA; myosin-IIIa
Background
The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. The protein encoded by this gene plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of this gene is highly restricted, with the strongest expression in retina and cochlea. [provided by RefSeq, Jul 2008]
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