Targets / Kinase / PAK1

p21 protein (Cdc42/Rac)-activated kinase 1 (PAK1)

Target Class
Kinase
Family
STE
Official Symbol
PAK1
Entrez Gene ID
5058
Species
Human
Accession Number
NP_002567.3
Alias Names
PAKalpha; STE20 homolog, yeast; alpha-PAK; p21 protein (Cdc42/Rac)-activated kinase 1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast); p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p65-PAK; serine/threonine-protein kinase PAK 1
Background
This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
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Related Group Members: STE
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