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eukaryotic translation initiation factor 2-alpha kinase 2 (PRKR)

Target Class
Kinase
Family
Other
Official Symbol
EIF2AK2
Entrez Gene ID
5610
Species
Human
Accession Number
NP_002750.1
Alias Names
EIF2AK1; P1/eIF-2A protein kinase; PKR; PRKR; double stranded RNA activated protein kinase; eIF-2A protein kinase 2; eukaryotic translation initiation factor 2-alpha kinase 2; interferon-induced, double-stranded RNA-activated protein kinase; interferon-inducible elF2alpha kinase; p68 kinase; protein kinase, interferon-inducible double stranded RNA dependent; tyrosine-protein kinase EIF2AK2
Background
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
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KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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