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v-raf-1 murine leukemia viral oncogene homolog 1 (RAF1)

Target Class
Kinase
Family
TKL
Official Symbol
RAF1
Entrez Gene ID
5894
Species
Human
Accession Number
NP_002871.1
Alias Names
CRAF; NS5; Oncogene RAF1; RAF proto-oncogene serine/threonine-protein kinase; Raf-1; c-Raf; proto-oncogene c-RAF; raf proto-oncogene serine/threonine protein kinase; v-raf-1 murine leukemia viral oncogene homolog 1
Background
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]
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Related Group Members: TKL
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KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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