ret proto-oncogene (RET(V804L))

Target Class
Official Symbol
Entrez Gene ID
Accession Number
Alias Names
CDHF12; CDHR16; HSCR1; Hirschsprung disease 1; MEN2A; MEN2B; MTC1; PTC; RET transforming sequence; RET-ELE1; RET51; cadherin family member 12; cadherin-related family member 16; hydroxyaryl-protein kinase; multiple endocrine neoplasia and medullary thyroid carcinoma 1; proto-oncogene c-Ret; proto-oncogene tyrosine-protein kinase receptor Ret; receptor tyrosine kinase; ret proto-oncogene; ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)
This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jul 2008]
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KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan