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receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1)

Target Class
Kinase
Family
TKL
Official Symbol
RIPK1
Entrez Gene ID
8737
Species
Human
Accession Number
NP_003795.2
Alias Names
RIP; RIP-1; RIP1; cell death protein RIP; receptor (TNFRSF)-interacting serine-threonine kinase 1; receptor interacting protein; receptor-interacting protein 1; receptor-interacting serine/threonine-protein kinase 1; serine/threonine-protein kinase RIP
Background
Serine-threonine kinase which transduces inflammatory and cell-death signals (necroptosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necroptosis-inducing complex.
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Solution Portfolio

Related Group Members: TKL
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Assay Measures Background Species Cell Line
Intracellular Binding Jurkat 96-0076C19
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
Available Available