Targets / Kinase / S6K1

ribosomal protein S6 kinase, 70kDa, polypeptide 1 (S6K1)

Target Class
Kinase
Family
AGC
Official Symbol
RPS6KB1
Entrez Gene ID
6198
Species
Human
Accession Number
NP_003152.1
Alias Names
70 kDa ribosomal protein S6 kinase 1; P70S6K1; PS6K; S6K; S6K-beta-1; S6K1; STK14A; p70 S6 kinase, alpha 1; p70 S6 kinase, alpha 2; p70 S6K-alpha; p70 S6KA; p70(S6K)-alpha; p70-S6K; p70-alpha; ribosomal protein S6 kinase I; ribosomal protein S6 kinase beta-1; ribosomal protein S6 kinase, 70kD, polypeptide 1; ribosomal protein S6 kinase, 70kDa, polypeptide 1; serine/threonine kinase 14 alpha; serine/threonine-protein kinase 14A
Background
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding this gene and overexpression of this kinase are seen in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
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