Targets / Kinase / SNARK

NUAK family, SNF1-like kinase, 2 (SNARK)

Target Class
Kinase
Family
CAMK
Official Symbol
NUAK2
Entrez Gene ID
81788
Species
Human
Accession Number
NP_112214.1
Alias Names
NUAK family SNF1-like kinase 2; NUAK family, SNF1-like kinase, 2; SNARK; SNF1/AMP activated protein kinase; SNF1/AMP kinase-related kinase; omphalocele kinase 2
Background
Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95- activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1.
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Solution Portfolio

Related Group Members: CAMK
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