Targets / Kinase / SRC

SRC proto-oncogene, non-receptor tyrosine kinase

Target Class
Kinase
Family
TK
Official Symbol
SRC
Entrez Gene ID
6714
Species
Human
Accession Number
NP_005408.1
Alias Names
ASV; SRC1; c-SRC; p60-Src; proto-oncogene c-Src; proto-oncogene tyrosine-protein kinase Src; protooncogene SRC, Rous sarcoma; tyrosine kinase pp60c-src; tyrosine-protein kinase SRC-1; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
Background
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
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