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serine/threonine kinase 36 (STK36)

Target Class
Kinase
Family
Other
Official Symbol
STK36
Entrez Gene ID
27148
Species
Human
Accession Number
NP_056505.1
Alias Names
FU; fused homolog; serine/threonine kinase 36; serine/threonine kinase 36 (fused homolog, Drosophila); serine/threonine-protein kinase 36
Background
This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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