Targets / Kinase / STK36

serine/threonine kinase 36 (STK36)

Target Class
Kinase
Family
Other
Official Symbol
STK36
Entrez Gene ID
27148
Species
Human
Accession Number
NP_056505.1
Alias Names
FU; fused homolog; serine/threonine kinase 36; serine/threonine kinase 36 (fused homolog, Drosophila); serine/threonine-protein kinase 36
Background
This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
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