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TAO kinase 1 (TAOK1)

Target Class
Kinase
Family
STE
Official Symbol
TAOK1
Entrez Gene ID
57551
Species
Human
Accession Number
NP_065842.1
Alias Names
KFC-B; MAP3K16; MARK Kinase; MARKK; PSK-2; PSK2; STE20-like kinase PSK2; TAO kinase 1; TAO1; hKFC-B; hTAOK1; kinase from chicken homolog B; microtubule affinity regulating kinase kinase; prostate-derived STE20-like kinase 2; prostate-derived sterile 20-like kinase 2; serine/threonine protein kinase TAO1 homolog; serine/threonine-protein kinase TAO1; thousand and one amino acid protein 1; thousand and one amino acid protein kinase 1
Background
Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade.
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Related Group Members: STE
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KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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