Targets / Kinase / TAOK3

TAO kinase 3 (TAOK3)

Target Class
Kinase
Family
STE
Official Symbol
TAOK3
Entrez Gene ID
51347
Species
Human
Accession Number
NP_057365.2
Alias Names
CTCL-associated antigen HD-CL-09; DPK; JIK; JNK/SAPK-inhibitory kinase; MAP3K18; STE20-like kinase; TAO kinase 3; cutaneous T-cell lymphoma-associated antigen HD-CL-09; dendritic cell-derived protein kinase; hKFC-A; jun kinase-inhibitory kinase; kinase from chicken homolog A; serine/threonine-protein kinase TAO3; thousand and one amino acid protein 3
Background
Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress- activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF).
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