Targets / Kinase / TBK1

TANK-binding kinase 1 (TBK1)

Target Class
Kinase
Family
Other
Official Symbol
TBK1
Entrez Gene ID
29110
Species
Human
Accession Number
NP_037386.1
Alias Names
NAK; NF-kB-activating kinase; NF-kappa-B-activating kinase; T2K; TANK-binding kinase 1; serine/threonine-protein kinase TBK1
Background
The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. [provided by RefSeq, Oct 2010]
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