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tyrosine kinase with immunoglobulin-like and EGF-like domains 1 (TIE1)

Target Class
Kinase
Family
TK
Official Symbol
TIE1
Entrez Gene ID
7075
Species
Human
Accession Number
NP_005415.1
Alias Names
JTK14; TIE; tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1; tyrosine kinase with immunoglobulin-like and EGF-like domains 1; tyrosine-protein kinase receptor Tie-1
Background
This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
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Related Group Members: TK
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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