Targets / Kinase / TLK1

tousled-like kinase 1 (TLK1)

Target Class
Kinase
Family
Other
Official Symbol
TLK1
Entrez Gene ID
9874
Species
Human
Accession Number
NP_036422.3
Alias Names
PKU-beta; SNARE protein kinase SNAK; serine threonine protein kinase; serine/threonine-protein kinase tousled-like 1; tousled-like kinase 1
Background
The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
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