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tyrosine kinase, non-receptor, 1 (TNK1)

Target Class
Kinase
Family
TK
Official Symbol
TNK1
Entrez Gene ID
8711
Species
Human
Accession Number
NP_003976.2
Alias Names
CD38 negative kinase 1; non-receptor tyrosine-protein kinase TNK1; tyrosine kinase, non-receptor, 1
Background
The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
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Solution Portfolio

Related Group Members: TK
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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