Targets / Kinase / TNK2

tyrosine kinase, non-receptor, 2 (TNK2)

Target Class
Kinase
Family
TK
Official Symbol
TNK2
Entrez Gene ID
10188
Species
Human
Accession Number
NP_001010938.1
Alias Names
ACK; ACK-1; ACK1; activated CDC42 kinase 1; activated Cdc42-associated kinase 1; activated p21cdc42Hs kinase; p21cdc42Hs; tyrosine kinase non-receptor protein 2; tyrosine kinase, non-receptor, 2
Background
This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
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Related Group Members: TK
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