Targets / Kinase / TrkC-P75
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Neurotrophic tyrosine kinase receptor type 3 (NTRK3)

Target Class
Kinase
Family
Receptor Tyrosine Kinase
Official Symbol
TrkC-P75
Species
Human
Accession Number
NM_001012338
Alias Names
ETS related protein-neurotrophic receptor tyrosine kinase fusion protein; ETV6-NTRK3 fusion; GP145-TrkC; NT-3 growth factor receptor; TRKC; gp145(trkC); neurotrophic tyrosine kinase, receptor, type 3; tyrosine kinase receptor C
Background
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
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Solution Portfolio

Related Group Members: Receptor Tyrosine Kinase
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Cell Lines
Assay Measures Background Species Cell Line
Receptor Phosphorylation U2OS Human 93-0531C3
Ready to Use eXpress Kits
Assay Measures Background Species Assay Kit
Receptor Phosphorylation U2OS Human 93-0531E3CP16M
Receptor Phosphorylation U2OS Human 93-0531E3CP16L
LeadHunter Screening & Profiling Services
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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