Targets / Kinase / TYK2(JH2domain-pseudokinase)

tyrosine kinase 2 (TYK2(JH2domain-pseudokinase))

Target Class
Kinase
Family
TK
Official Symbol
TYK2
Entrez Gene ID
7297
Species
Human
Accession Number
NP_003322.3
Alias Names
JTK1; non-receptor tyrosine-protein kinase TYK2; tyrosine kinase 2
Background
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
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Related Group Members: TK
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