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tyrosine kinase 2 (TYK2(JH2domain-pseudokinase))

Target Class
Kinase
Family
TK
Official Symbol
TYK2
Entrez Gene ID
7297
Species
Human
Accession Number
NP_003322.3
Alias Names
JTK1; non-receptor tyrosine-protein kinase TYK2; tyrosine kinase 2
Background
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
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Related Group Members: TK
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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