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unc-51-like kinase 3 (ULK3)

Target Class
Kinase
Family
Other
Official Symbol
ULK3
Entrez Gene ID
25989
Species
Human
Accession Number
NP_001092906.1
Alias Names
serine/threonine-protein kinase ULK3; unc-51-like kinase 3 (C. elegans)
Background
Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.
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KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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