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kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGFR2)

Target Class
Kinase
Family
TK
Official Symbol
KDR
Entrez Gene ID
3791
Species
Human
Accession Number
NP_002244.1
Alias Names
CD309; FLK1; VEGFR; VEGFR2; fetal liver kinase 1; fetal liver kinase-1; kinase insert domain receptor (a type III receptor tyrosine kinase); protein-tyrosine kinase receptor Flk-1; soluble VEGFR2; tyrosine kinase growth factor receptor; vascular endothelial growth factor receptor 2
Background
Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]
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KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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