Targets / Kinase / WEE1

WEE1 G2 checkpoint kinase (WEE1)

Target Class
Kinase
Family
Other
Official Symbol
WEE1
Entrez Gene ID
7465
Species
Human
Accession Number
NP_003381.1
Alias Names
WEE1 homolog (S. pombe); WEE1+ homolog; WEE1A; WEE1hu; wee1+ (S. pombe) homolog; wee1-like protein kinase; wee1A kinase
Background
This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. [provided by RefSeq, Jul 2008]
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