Targets / Kinase / ZAP70

zeta-chain (TCR) associated protein kinase 70kDa (ZAP70)

Target Class
Kinase
Family
TK
Official Symbol
ZAP70
Entrez Gene ID
7535
Species
Human
Accession Number
NP_997402.1
Alias Names
70 kDa zeta-associated protein; 70 kDa zeta-chain associated protein; SRK; STD; TZK; ZAP-70; syk-related tyrosine kinase; tyrosine-protein kinase ZAP-70; zeta-chain (TCR) associated protein kinase (70 kD); zeta-chain (TCR) associated protein kinase 70kDa; zeta-chain associated protein kinase, 70kD
Background
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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