Targets / Nuclear Receptors / ERα
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Estrogen receptor 1 (ESR1)

Target Class
NHR
Family
NHR
Official Symbol
ERα
Species
Human
Accession Number
NM_000125
Alias Names
ER; ER-alpha; ESR; ESRA; Era; NR3A1; estradiol receptor; estrogen nuclear receptor alpha; estrogen receptor; estrogen receptor 1; estrogen receptor alpha 3 ,4,5,6,7 /822 isoform; estrogen receptor alpha delta 3 ,4,5,6,7 ,8 /941 isoform; estrogen receptor alpha delta 3 ,4,5,6,7 /819-2 isoform; estrogen receptor alpha delta 4 +49 isoform; estrogen receptor alpha delta 4 ,5,6,7 /654 isoform; estrogen receptor alpha delta 4 ,5,6,7,8 /901 isoform; nuclear receptor subfamily 3 group A member 1
Background
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Technology:

Cell Based Protein Interaction
?

DiscoveRx Protein Interaction Assays are cell-based assays designed to measure protein interaction in engineered cell lines using our proprietary EFC technology. The interaction can be triggered by protein activation/inactivation and is the basis of several DiscoveRx cell based assays including the Arrestin and the Kinase assays. Learn more about our Cell Based Protein Interaction Assays.

 , Cell Based Translocation
?

DiscoveRx Protein Translocation Assays are cell-based assays designed to measure protein translocation in engineered cell lines using our proprietary EFC technology. The translocation can occur to either the endosome, membrane, cytosol or nucleus and can be triggered by protein activation/inactivation. This forms the basis of several DiscoveRx cell based assays including the GPCR Internalization and the NHR Translocation assays. Learn more about our Cell Based Translocation Assays.

 , Biochemical
?

DiscoveRx Biochemical Assays are designed as homogenous, competitive in vitro assays for precise, highly sensitive detection of specific analytes, protein binding or protease cleavage. These highly robust, reliable assays are anchored in our proprietary EFC technology, minimizing false positive due to autofluorescence and are HTS compatible. Learn more about our Biochemical Assays.


Related Target Members:

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Cell Lines
Assay Readout Background Species Cell Line
Chemiluminescence CHO-K1 Human 93-0453C2
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