Targets / Nuclear Receptors / LXRα
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Nuclear receptor subfamily 1, group H, member 3 (Liver X receptor α) (NR1H3)

Target Class
NHR
Family
NHR
Official Symbol
LXRα
Species
Human
Accession Number
NM_005693
Alias Names
LXR-a; LXRA; RLD-1; liver X nuclear receptor alpha variant 1; nuclear receptor subfamily 1, group H, member 3; oxysterols receptor LXR-alpha
Background
The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
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Solution Portfolio

Technology:

Cell Based Protein Interaction
?

DiscoveRx Protein Interaction Assays are cell-based assays designed to measure protein interaction in engineered cell lines using our proprietary EFC technology. The interaction can be triggered by protein activation/inactivation and is the basis of several DiscoveRx cell based assays including the Arrestin and the Kinase assays. Learn more about our Cell Based Protein Interaction Assays.

 , Cell Based Translocation
?

DiscoveRx Protein Translocation Assays are cell-based assays designed to measure protein translocation in engineered cell lines using our proprietary EFC technology. The translocation can occur to either the endosome, membrane, cytosol or nucleus and can be triggered by protein activation/inactivation. This forms the basis of several DiscoveRx cell based assays including the GPCR Internalization and the NHR Translocation assays. Learn more about our Cell Based Translocation Assays.

 , Biochemical
?

DiscoveRx Biochemical Assays are designed as homogenous, competitive in vitro assays for precise, highly sensitive detection of specific analytes, protein binding or protease cleavage. These highly robust, reliable assays are anchored in our proprietary EFC technology, minimizing false positive due to autofluorescence and are HTS compatible. Learn more about our Biochemical Assays.


Related Target Members:

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Cell Lines
Assay Readout Background Species Cell Line
Chemiluminescence CHO-K1 Human 93-0215C2
Chemiluminescence CHO-K1 Human 93-0389C2
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