GPCR Targets

World’s Largest Portfolio, Multiple Signaling Pathways

G-protein coupled receptors (GPCRs) represent a large class of important therapeutic targets. To simplify and speed exploration of GPCR biology and drug discovery, Eurofins DiscoverX offers an industry-largest portfolio GPCR cell lines and cell-based assays designed to detect GPCR signaling through second messenger activation, arrestin recruitment, and receptor internalization. Our broad collection of human and ortholog GPCR assays in a wide variety of functional readouts gives you complete flexibility to choose the ideal screening platform that meets your specific project needs. Regardless of the technology platform, Eurofins DiscoverX provides the most robust, reliable, and high-throughput-friendly GPCR assays available.

GPCR Solutions
Learn more about the updated Cell Culture and Handling Procedure in the new Technical Bulletin.

View by GPCR Receptor Family

5-Hydroxytryptamine 5-Hydroxytryptamine HTR1A HTR1B HTR1E HTR1F HTR2A HTR2B HTR2C HTR2C(VGV) HTR2C(VNV) HTR2C(VSV) HTR5A HTR6 HTR7A HTR7B HTR7D mHTR2A mHTR2C rHTR2C	Acetylcholine Acetylcholine CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 rCHRM4	Adenosine Adenosine ADORA1 ADORA2A ADORA2B ADORA3 mADORA2B mADORA3	Adrenoceptors Adrenoceptors ADRA1A ADRA1B ADRA1D(82-572) ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ADRB2(W158A) ADRB3 mADRA1B	Angiotensin Angiotensin AGTR1
Apelin Apelin AGTRL1 mAGTRL1	Bile acid Bile acid GPBAR1	Bombesin Bombesin BRS3 GRPR mBRS3 NMBR	Bradykinin Bradykinin BDKRB1 BDKRB2	Calcitonin Calcitonin CALCR CALCRL-RAMP1 CALCRL-RAMP2 CALCRL-RAMP3 CALCR-RAMP2 CALCR-RAMP3
Calcium sensing Calcium sensing CASR	Cannabinoid Cannabinoid CNR1 CNR2 mCNR1 mCNR2 rCNR2	Chemerin Chemerin CMKLR1	Chemokine Chemokine CCR1 CCR10 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9 CCRL1 CCRL2 CX3CR1 CXCR1 CXCR2 CXCR3 CXCR4 CXCR5 CXCR6 CXCR7 cyno CXCR1 cyno CXCR2 DARC mCCR1 mCCR2 mCCR3 mCCR4 mCCR5 mCCR6 mCCR7 mCCR8 mCCR9 mCMKLR1 mCX3CR1 mCXCR2 mCXCR3 mCXCR4 mCXCR5 mCXCR6 mCXCR7 XCR1	Cholecystokinin Cholecystokinin CCKAR CCKBR mCCKAR
Class A Orphan Class A Orphan cGPR91 cyno MRGPRX2 EBI2 GHSR1b GPR1 GPR101 GPR119 GPR12 GPR132 GPR135 GPR139 GPR141 GPR142 GPR146 GPR148 GPR149 GPR15 GPR150 GPR151 GPR152 GPR161 GPR162 GPR17 GPR171 GPR173 GPR176 GPR18 GPR182 GPR20 GPR22 GPR23 GPR25 GPR26 GPR27 GPR3 GPR31 GPR32 GPR35 GPR37 GPR37L1 GPR39 GPR4 GPR45 GPR50 GPR52 GPR55 GPR6 GPR61 GPR65 GPR75 GPR78 GPR79 GPR83 GPR84 GPR85 GPR88 LGR4 LGR5 LGR6 mEBI2 mGPR1 mGPR84 MRGPRD MRGPRE MRGPRF MRGPRX1 MRGPRX2 MRGPRX4 OPN5 OXGR1 P2RY8 rGPR35 TAAR5	Class B Orphan Class B Orphan BAI1 BAI2 BAI3 GPR123 GPR157 GPR97	Complement peptide Complement peptide C3AR1 C5AR1 C5L2 mC5AR1	Corticotropin-releasing factor Corticotropin-releasing factor CRHR1 CRHR2 mCRHR1	Dopamine Dopamine DRD1 DRD2L DRD2S DRD3 DRD4 DRD5 mDRD5 rDRD1 rDRD2L rDRD2S
Endothelin Endothelin EDNRA EDNRB mEDNRA mEDNRB	Estrogen (G protein coupled) receptor Estrogen (G protein coupled) receptor GPR30	Formylpeptide Formylpeptide FPR1 FPR3 FPRL1 mFPR1 mFPR2	Free Fatty Acid Free Fatty Acid cyno GPR120 FFAR1 FFAR2 FFAR3 GPR120 GPR120S mFFAR1 mGPR120 rFFAR1 rGPR120	Frizzled Frizzled SMO(W535L)
GABAB GABAB GABBR1-GABBR2	Galanin Galanin GALR1 GALR2 mGALR1 mGALR2	Ghrelin Ghrelin GHSR mGHSR	Glucagon Glucagon GCGR GHRHR GIPR GLP1R GLP2R mGCGR mGIPR mGLP1R mGLP1R-ADCY2 SCTR	Glycoprotein hormone receptor Glycoprotein hormone receptor FSHR LHCGR TSHR(L)
Gonadotropin-releasing hormone Gonadotropin-releasing hormone GNRHR	Histamine Histamine HRH1 HRH2 HRH3 HRH4	Hydroxycarboxylic acid Hydroxycarboxylic acid GPR109A GPR109B GPR81	Kisspeptin receptor Kisspeptin receptor KISS1R	Leukotriene Leukotriene CYSLTR2 LTB4R mLTB4R OXER1
Lysophospholipid (LPA) Lysophospholipid (LPA) EDG2 EDG4 EDG7 GPR92	Lysophospholipid (S1P) Lysophospholipid (S1P) cEDG5 EDG1 EDG3 EDG5 EDG6 mEDG1 mEDG3 mEDG5 rEDG5 sEDG5	Melanin-concentrating hormone Melanin-concentrating hormone MCHR1 MCHR2 mMCHR1	Melanocortin Melanocortin MC1R MC3R MC4R MC4R(T162I) MC5R mMC3R mMC4R mMC5R	Melatonin Melatonin MTNR1A MTNR1B
Metabotropic glutamate Metabotropic glutamate GRM1 GRM2 GRM3 GRM4 GRM5 GRM6	Motilin Motilin MLNR	Neuromedin U Neuromedin U NMU1R	Neuropeptide B & W Neuropeptide B & W NPBWR1 NPBWR2	Neuropeptide FF & AF Neuropeptide FF & AF NPFFR1
Neuropeptide S Neuropeptide S NPSR1b	Neuropeptide Y Neuropeptide Y mNPY1R mNPY2R mPPYR1 NPY1R NPY2R PPYR1	Neurotensin Neurotensin NTSR1	Opioid Opioid mOPRD1 mOPRK1 mOPRM1 OPRD1 OPRK1 OPRL1 OPRM1 rOPRM1	Orexin Orexin HCRTR1 HCRTR2 mHCRTR1
Other 7TM proteins Other 7TM proteins GPR107 GPR137 GPR143	P2Y P2Y mP2RY12 mP2RY6 P2RY1 P2RY11 P2RY12 P2RY2 P2RY4 P2RY6	Parathyroid hormone Parathyroid hormone PTHR1 PTHR2	Peptide P518 Peptide P518 GPR103	Platelet-activating factor Platelet-activating factor mPTAFR PTAFR
Prokineticin Prokineticin PROKR1 PROKR2 rPROKR1 rPROKR2	Prolactin releasing peptide receptor Prolactin releasing peptide receptor PRLHR	Prostanoid Prostanoid CRTH2 mCRTH2 mPTGER4 mPTGIR PTGDR PTGER1 PTGER2 PTGER3 PTGER4 PTGFR PTGIR rCRTH2 rPTGER4 TBXA2R	Protease activated Protease activated F2R F2RL1 F2RL3 mF2RL1	Relaxin Relaxin mRXFP1 mRXFP3 mRXFP4 RXFP1 RXFP2 RXFP3 RXFP4
Rhodopsin Rhodopsin mRHO(P23H)	Somatostatin Somatostatin mSSTR2 mSSTR5 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5	Tachykinin Tachykinin mTACR1 TACR1 TACR2 TACR3	Thyrotropin releasing hormone Thyrotropin releasing hormone TRHR	Trace amine Trace amine mTAAR1 rTAAR1 TAAR1
Urotensin Urotensin mUTR2 UTR2	Vasopressin and Oxytocin Vasopressin and Oxytocin AVPR1A AVPR1B AVPR2 AVPR2(S167T) mAVPR2 mOXTR OXTR	VIP and PACAP VIP and PACAP ADCYAP1R1 mADCYAP1R1 mVIPR1 rVIPR1 VIPR1 VIPR2

Cell Lines

Eurofins DiscoverX offers the most comprehensive portfolio of stable, pre-validated GPCR cell lines to measure receptor signaling through second messenger, arrestin recruitment, and internalization readouts.

Assay Ready Kits

PathHunter® and cAMP Hunter™ eXpress GPCR assays are complete, ready-to-use kits that include all cells and reagents to perform functional GPCR assays in live cells. Free yourself from lengthy cell culture, expensive instrumentation, and complex assay development! Obtain robust, reliable, and high-throughput data in a chemiluminescent format.
Learn about Assay Ready kit formats >

Frozen Cells

Obtain quick results hassle-free with single-use cryopreserved cells with high cellular viability and resulting in large assay signal. These Ready-to-Assay™ GPCR frozen cells come with plating media and enough cells to run either 96- or 384-well plate assays in full or half plate formats. They are qualified for cAMP and calcium second messenger assays and provide results within 24 hours to accelerate your data generation.

Learn about all our available Frozen Cells >

ChemiScreen™ & ChemiBrite GPCR Frozen Cells

Membrane Preparations

Single-use, GPCR membrane preps for saturation and competitive Radioligand binding and GTPγS functional studies. Derived from ChemiScreen™ stable cell lines for superior cell surface expression and lot-to-lot consistency. Robust performance with excellent signal-to-background ratios, reproducible results, and specific and high total ligand binding.

Learn about all our available Membrane Preps >

ChemiScreen™ & ChemiBrite GPCR Membrane Preps

Second Messenger Assays

Study second messenger signaling using our suite of validated biochemical assays for highly quantitative determination of cAMP, cGMP, Calcium, or IP3 accumulation.
Learn about second messenger assays >

Cell Culture Kits, Reagents & Consumables

Performance you can trust! Get the highest quality data from your cell-based GPCR assays in combination with our lab-certified PathHunter® and HitHunter® cell culture media, tissue culture reagents, and plates.

Ligands and Inhibitors

Designed to target a specific GPCR receptor or pathway, our purified reference ligands and inhibitors are a convenient and cost-effective way to validate any stable GPCR cell line or assay-ready kit.

Control Ligands

Detection Reagents

Get optimal assay performance using certified chemiluminescent or fluorescent PathHunter® Detection Reagents that have been validated for use in both 96-well and 384-well microplate formats.