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Nuclear Hormone Receptors

Robust, Sensitive Assays with Full-Length NHR

Nuclear Hormone Receptors (NHRs) are ligand-activated transcription factors that, in concert with additional factors, regulate gene expression or repression and play a critical role in endocrine signaling. For discovery of novel compounds targeting NHRs, DiscoverX offers 26 cell-based assays with full-length NHR, which are ideal for measuring NHR transcriptional activation, translocation, and NHR-coactivator/corepressor interaction. Because our unique NHR assays do not require downstream transcriptional activation or lengthy 16-24 hour compound incubations characteristic of standard reporter gene assays, DiscoverX’s rapid protocols minimize cell toxicity and false positive rates, yielding results with high specificity.

Learn more about the updated Cell Culture and Handling Procedure in the new Technical Bulletin.

AR ERRα ERα FXR GR
LXRα LXRβ LXRβ-NCoR1 MR PPARα
PPARγ PPARδ PRα PRβ RARα
RARβ RXRα RXRγ THRα THRβ

Cell Lines

DiscoverX offers a comprehensive panel of stable, pre-validated cell lines with full-length NHR to measure nuclear translocation and protein interaction. 

Learn about the Nuclear Translocation assay principle >
Learn about the Protein Interaction assay principle >

Assay Ready Kits

PathHunter® eXpress NHR Assays are an extensive panel of complete, ready-to-use kits that include all cells and reagents to measure NHR translocation and NHR coactivator interaction in whole cells containing full-length NHRs. Free yourself from lengthy cell culture, expensive instrumentation, and complex assay development!

Learn about our assay ready kits >

Cell Culture Kits, Reagents & Consumables

Performance you can trust! Get the highest quality data from your cell-based NHR assays in combination with our lab-certified PathHunter® cell culture media, tissue culture reagents, and plates.

Ligands and Inhibitors

Designed to target a specific nuclear hormone receptor, our purified reference ligands and inhibitors are a convenient and cost-effective way to validate any stable NHR cell line or assay-ready kit.

Detection Reagents

Get optimal assay performance using certified chemiluminescent or fluorescent PathHunter® Detection Reagents that have been validated for use in both 96-well and 384-well microplate formats.