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Competitive Binding Technology

Active-site/Ligand Binding Technology Overview

DiscoverX's proprietary active-site/ligand binding technology affords investigators the ability to leverage a growing portfolio of services against multiple target classes and maximixe the value of novel and chemistry assets through all stages of drug discovery. This robust and reliable assay technology enables accurate, precise, reproducible and quantitative measurements of interactions between test compounds and the target protein.

Explore Target Biology With Multiple Technology Platforms

KINOMEscan  Active-site Directed Competition Binding Platform

The KINOMEscan screening platform employs a novel and proprietary active site-directed competition binding assay to quantitatively measure interactions between test compounds and more than 450  kinase assays and disease relevant mutant variants.

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BROMOscan℠ Bromodomain-ligand Binding Platform

Based on the proven KINOMEscan℠ technology platform, BROMOscan℠ employs a novel and proprietary bromodomain-ligand binding assay to quantitatively measure interactions between test compounds and a panel of bromodomain assays.

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InCELL Hunter™ Intracellular Binding Assay Platform

Employing EFC, the catalytic domain of the protein of interest is tagged with enhanced ProLabel (ePL). Complementation between the ePL and EA occurs only when compounds bind to the catalytic domain and stabilizes the protein of interest, increasing its half-life relative to the unbound protein.

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