[DOT 2022] InCELL Pulse: Cellular Target Engagement Assay Platform for Drug Discovery

[DOT 2022] InCELL Pulse: Cellular Target Engagement Assay Platform for Drug Discovery
Version:
21394

File Name/Number:
DOT

Year:
2022

 

It is well established that ligand binding can protect proteins from thermal denaturation in a cellular milieu; however, the broad application of this cellular target engagement concept to drug discovery has been hindered by a lack of simple platforms with sensitive quantitative readouts.