[PEGS 2023] Comprehensive & Fit-For-Purpose Solutions to Enable Drug Development for Cytokine Targets
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Interleukins are known for their involvement in functioning of both the adaptive and innate immune systems. Interleukins direct immune cells to divide and differentiate and are classied as either pro-inflammatory or anti-inflammatory. Interleukins and their receptors are well-validated targets for therapeutic intervention in immuno-oncology and for a variety of disorders, such as psoriatic arthritis, Crohn’s disease, and many other indications. Examples of interleukins that are current targets for therapeutic intervention with marketed drugs include, IL-2, IL-6, IL-4/IL-13, IL-17, and IL-23.