[User Manual] PathHunter® Checkpoint Assay - TNF Receptor Superfamily (TNFRSF)

[User Manual] PathHunter® Checkpoint Assay - TNF Receptor Superfamily (TNFRSF)
Version:
20845

File Name/Number:
70-395

Year:
2018

The PathHunter Checkpoint Signaling Assay for Tumor Necrosis Factor Receptor Superfamily (TNFRSF) members (or receptors) is a simple, highly specific assay to enable discovery and development of small molecule and biologic drugs targeting the TNFR superfamily of receptors that activate the non-canonical NF-kB pathway through NF-kB inducing kinase (NIK). The assay is a robust measurement of co-stimulatory checkpoint receptors using cells that express NIK. This has been developed for use with cell lines natively or exogenously expressing co-stimulatory receptors (e.g. cell lines engineered to express OX40 or CD137).